Complex Regional Pain Syndrome (CRPS) remains a perplexing and often devastating condition, falling under the broad category of neuropathic pain. Afflicting a staggering 50,000+ new cases in the United States annually, CRPS emerges as a relentless force, characterized by severe and unyielding pain triggered by traumatic events such as injuries, sprains, the loss of a loved one, or even strokes. Typically manifesting in the limbs, CRPS introduces an array of skin, nail, and hair changes along with temperature changes in the affected area. The hallmark of CRPS is central sensitization, where even a gentle touch can escalate into unbearable pain.

Histamine is a biogenic amine present in various body tissues, including the brain, heart, lungs, and intestines. It plays a crucial role in physiological processes such as the immune response, inflammation, and neurotransmission. Stored in mast cells and basophils, types of immune cells, histamine is released into surrounding tissues upon cell activation, binding to histamine receptors and inducing various effects. Estrogen, a hormone produced by the ovaries, is a key trigger for histamine release and impacts the female reproductive system.

The main concern with Low Dose Naltrexone (LDN) and any surgery is the possibility of needing to take an opioid painkiller for a short time post surgery. Opioids like Percocet, Lortab, and Oxycontin cannot be taken in conjunction with LDN because they bind to the same receptors, your OGFR receptors. If you are taking LDN and then try to take a painkiller, it’s possibly the receptors will be blocked by the LDN and you will not receive relief from the post surgical pain.